Typically not. The Sonnet USB 3.0 ExpressCard/34 can supply only USB low power specification power (500mA@5V = 2.5W) for only one low-powered device. However, 2.5" USB 3.0 drives typically require 3.5-4.5W and will not start unless external power is applied to the storage device. Some customers have had success using a LaCie USB 3.0 Y cable, which will draw power for the drive from the computer's USB port. http://www.lacie.com/us/products/product.htm?id=10572