If you are connecting from a DVI (or sometimes DP) port on your GPU Card--via an adapter cable--to an HDMI port on your monitor and the display looks magenta, you can fix the issue in the monitor control panel. Go to the monitor Color Settings; select Input Color Format; change from RGB to YPbPr. That should solve the problem.
Connect one 4k monitor to the DP port.
Connect one 4k monitor to HDMI port.
Connect two 4k monitors a Sonnet Thunderbolt 3 to Dual DP or Dual HDMI adapter connected to the Thunderbolt 3 port.
macOS does not support disconnecting or powering off an eGPU during sleep. If you do so, your Mac will kernel panic. This is an issue that persists through at least macOS 11.2.3. Sonnet has reported the issue to Apple.