One should insert CF cards into the slots only when the adapter card is ejected because the interface to CF cards is ATA and ATA can only instantiate itself to the system when the adapter card is inserted. You can unmount and then remove CF cards when the adapter is inserted, but you can't plug in new ones unless you first power off and eject the adapter card.
The Echo ExpressCard/34 Thunderbolt adapter requires Mac OS 10.6.8 or later and supports cards with Thunderbolt technology-aware drivers. Download and install the latest driver to make your card compatible:
Note: Sonnet FireWire 800 Pro ExpressCard/34, and FireWire/USB ExpressCard/34 cards are compatible without additional drivers. For third-party products listed as compatible, please visit those manufacturer's Websites to get the latest, Thunderbolt technology-aware drivers.