Yes, this is a great way to expand capacity and performance. If two or more Tempo-X, X4+4, X8, X4i, X4P, E4i, or E4P cards are installed to the same machine they must all have the same firmware version to avoid conflicts.
Under Mac OS X 10.3 and 10.4, a volume greater than 2TB will show as a 2TB volume due to a limitation in Apple's ATA layer (just above the driver). Sonnet plans to provide a 10.4 fix in the next driver release. Under Mac OS X 10.5 and 10.6, the full capacity of the RAID volume is available.