Spread Spectrum Clocking is a way to lower electromagnetic interference or EMI. This is important for storage solutions that are required to pass FCC and other agency certifications. All current Serial ATA disk drives implement SSC (some allow you to turn this feature on/off). However, some older SATA drives do not implement SSC. All Sonnet Serial ATA host adapter cards support SSC but will also work with disk drives that do not.
Macintosh bootable volumes are supported on the internal 2-port PCI card (part number TSATA) but are not supported on any of the other SATA cards at this time.
The new 3 Gigabit/second eSATA cards contain a rather large Marvell chip with the string "88SX6081" on it. Previous generation eSATA cards had a Marvell chip labeled "88SX5081". Additionally, you can check your Macintosh System Profile. When you select the installed eSATA card, the Device ID will show either "0x6081" or "0x5081".