Often, yes. Sometimes, not. Some other manufacturers' drivers may incorrectly assume a Sonnet card is their SATA card which may cause havoc. The symptoms include significantly slower performance, driver not loading, or both drivers loading and causing and kernel panics as they both try to access the same card. Sonnet recommends removing other manufacturer's card(s) and driver(s) if a problem of this type occurs.
Sonnet has tested the following cards with the Drobo S:
Tempo SATA E2P..............................compatible
Tempo SATA E4P..............................not compatible
Tempo SATA ExpressCard/34...........compatible
Tempo SATA Edge ExpressCard/34...compatible
Tempo SATA Pro ExpressCard/34.....not compatible
Tempo SATA X4P..............................not compatible
Qio eSATA ports...............................not compatible