Sonnet has tested the following cards with the Drobo S:
Tempo SATA E2P..............................compatible
Tempo SATA E4P..............................not compatible
Tempo SATA ExpressCard/34...........compatible
Tempo SATA Edge ExpressCard/34...compatible
Tempo SATA Pro ExpressCard/34.....not compatible
Tempo SATA X4P..............................not compatible
Qio eSATA ports...............................not compatible
A Lion install removes the driver for the Tempo SATA E2P, Tempo SATA ExpressCard/34, and Tempo SATA edge ExpressCard/34. Just reinstall the driver and the card will work again.
Unfortunately, not. The driver was written by the 3Gb SATA controller chip maker, Silicon Image, and they no longer maintain the macOS driver for this chip.