The first time you boot with the Qio connected, the screen will stay blue for up to 6 minutes while the Mac is configuring the Qio slot space. Please be patient. Subsequent boots should be normal. Note that you must install the Qio software before connecting the Qio.
This issue is now resolved. The Panasonic P2 driver included with Qio software version 1.2.3 and later is 64-bit compatible. Installing Qio 1.3.2 or later adds P2 support to systems running OS X in 64-bit mode, including Mavericks (10.9) and Yosemite (10.10)