Sonnet has tested the following cards with the Drobo S:
Tempo SATA E2P..............................compatible
Tempo SATA E4P..............................not compatible
Tempo SATA ExpressCard/34...........compatible
Tempo SATA Edge ExpressCard/34...compatible
Tempo SATA Pro ExpressCard/34.....not compatible
Tempo SATA X4P..............................not compatible
Qio eSATA ports...............................not compatible
Using a Drobo S with a Macintosh and Sonnet Tempo SATA E2P, Tempo SATA ExpressCard/34, or Tempo SATA Edge ExpressCard/34. you may get a device removal error after waking up from sleep. The Drobo S will automatically reconnect. System caches are flushed before sleep, so there is not data loss.
Unfortunately, not. The driver was written by the 3Gb SATA controller chip maker, Silicon Image, and they no longer maintain the macOS driver for this chip.