Macintosh bootable volumes are supported on the internal 2-port PCI card (part number TSATA) but are not supported on any of the other SATA cards at this time.
Our testing has shown that a four-drive array will sustain maximum reads and writes of about 200 MB/second in a 64bit, 33MHz PCI slot. An eight-drive array will not provide any additional performance beyond that of a four-drive array in that slot. To get significantly more performance, you need to use a machine with a PCI-X slot.
Sonnet has tested the following cards with the Drobo S:
Tempo SATA E2P..............................compatible
Tempo SATA E4P..............................not compatible
Tempo SATA ExpressCard/34...........compatible
Tempo SATA Edge ExpressCard/34...compatible
Tempo SATA Pro ExpressCard/34.....not compatible
Tempo SATA X4P..............................not compatible
Qio eSATA ports...............................not compatible